Is NDM-1 the new swine flu?
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M$10 Answers
NDM -1 is an enzyme called “New Delhi Metallo-beta-lactamase-1”, or “NDM-1”. It is originated from India, so the name is NDM-1. The enzyme NDM-1 is found inside bacteria (not virus), like Klebsiella pneumoniae, E. coli, and makes the bacteria extremely virulent and resistant to most antibiotics. No effective antibiotic is available against NDM-1 (New Delhi Metallo-beta-lactamase-1), present drugs (antibiotics) are resistant to NDM-1. Scientists have warned that a new enzyme called New Delhi-Metallo-1 could make all bacteria resistant to almost all antibiotic.
The health experts are warning that NDM-1 could become a worldwide health hazard. The NDM-1 superbug is already widespread in India and Pakistan. Moreover, 37 cases has already been reported in UK. Similar bugs have already been detected in the U.S., Canada, Australia and the Netherlands.
Health Travelers (person who will travel for health purposes) to India should abstain at the present time to take any cheap cosmetic surgery from India, Pakistan, Bangladesh, Nepal, Bhutan, etc. due to the NDM-1 superbug.
At present there is less possibility to announce global pandemic like the H1N1 by the WHO.
-quote
In fact, 14 of the infected U.K. patients had traveled to India or Pakistan for medical care, mostly plastic surgery. That kind of "medical tourism" could lead NDM-1 to make quick headway toward dangerous world domination.
"Because of medical tourism and international travel in general, resistance to these types of bacteria has the potential to spread around the world very, very quickly," Dr. Timothy Walsh, the study's lead author, told ABC News. "And there is nothing in the (drug development) pipeline to tackle it."
-/quote-
http://www.aolnews.com/surge-desk/article/what-is-the-ndm-1-superbug
www.bbc.co.uk/news/health-10930031
www.dailymail.co.uk/.../NDM-1-Alert-unbeatable-superbug-spread-worldwide.html
www.huffingtonpost.com/.../11/ndm-1-new-superbug-gene-c_n_678427.html
www.bbc.co.uk/news/health-10925411
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M$
And for your second question @coreymac, yes, the world should be concerned about this because it already has infected a number of persons and is predicted to spread globally. And whether the World Health Organization will announce this as a global pandemic scare, I most probably see that it’s likely. And I hope they’d do soon in order to alert the whole world while early so this can be prevented from spreading further.
opinion about reports
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The major fear is that the NDM-1 enzyme is produced by strands of DNA which can be easily transferred from one bacterium to another. It was discovered that two normally ‘’harmless’’ bacteria (Escherichia coli and Klebsiella pneumonia) found in the gut of humans, have become associated with the NDM-1 enzyme. If this gene for producing NDM-1 is passed to a group of common bacteria that are already resistant to antibiotics, a total health chaos would be produced.
http://www.youtube.com/watch?v=K1axIgJ1VC0&feature=player_embedded
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There are antibiotics that can be used to treat NDM-1. Granted, people who are very ill with NDM-1 are at risk for death, but the risks of a healthy person contracting it are not huge, unless you go to a country in which it is prevalent and have surgery and contract the infection and fail to get treament in a timely manner.
I apologize if I sound less concerned than some think I should be. I am just tired of reacting in fear to so much media hype that wants us to be afraid. I don't think it makes for a healthy society and I would hope we would just educate ourselves and then be proactive to reduce risks as much as possible. And have a happy life.
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5810a4.htm
http://www.cdc.gov/mmwr/PDF/wk/mm5924.pdf
Thirty years as a nurse and nurse midwife
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M$NDM-1 is genetically altering bacteria making that bacteria a carbapenem resistant bacteria and therefor very difficult to treat. Carbapenems are the last resort treatments for many bacterial infections and the strongest of antibiotics.
NDM-1 makes bacteria.. any bacteria.. able to outlast the strongest of our treatments by altering the bacteria at the DNA genetic level.
"There are currently no new antibiotics in the pipeline to combat bacteria resistant to carbapenems, and worldwide spread of the resistance gene is considered a nightmare scenario" (1)
As of right now the chief bacteria infected by and therefore genetically altered by NDM-1 is E. Coli but this has a very good chance of changing and then there will be several different types of bacterial infections all being hyper resistant to treatments by the strongest antibiotics we have to treat them with.
"Also worrying was that the gene was found on plasmids — bits of mobile DNA that can jump easily from one bacteria strain to another."(2)
So while NDM-1 will not be "the next swine flu" NDM-1 will be effecting E. Coli and other bacterias and these genetically altered bacterias will be very resistant to treatments. There can only be speculation as to what other bacteria besides E. Coli that will be effected by the genetic alteration of NDM-1.
Whatever very harmful bacteria (bacterial meningitis?) that gets altered by DSM-1 will be the nest swine flu.. just a guess form here at this point as to what that bacteria will be.
"And experts fear NDM-1 could now jump to other strains of bacteria that are already resistant to many other antibiotics.
Ultimately, this could produce dangerous infections that would spread rapidly from person to person and be almost impossible to treat." (3)
NO new antibiotics to combat bacteria resistant to carbapenems.
None. Zip. Nada. No treatments.
That is a very scary statement and easily brings nightmare scenarios of world wide drug resistant infection by a yet to be known bacteria, possibly E. Coli or bacterial meningitis, to mind.
Get out and stock up on the antibiotic hand gel again.
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NONE? I will argue with that. See link.
http://www.google.com/hostednews/canadianpress/article/ALeqM5iTu6FVJuSJQmYS4y-n29VJ7ZOTCA
I will have to edit that statement to now say "Canadian doctors have found a successful cocktail of antibiotics to treat one specific NDM-1 genetically altered bacteria"
The Canadian Press news article provided does not say what type of bacteria was treated only that it was an altered by NDM-1 .. that provides a little light and hope. If one NDM-1 altered strain of some unknown bacteria has been successfully treated maybe another could be as well.
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M$You can leave an optional "tip" with Mahalo's virtual currency, Mahalo Dollars. If you are asking a difficult question that might require some research, or if you'd like a wide variety of feedback, a higher tip often leads to more answers to your question.
M$
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M$Heres is the link:
http://www.ncbi.nlm.nih.gov/pubmed/19770275
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However as we seen with the swine flu, the super bugs hit otherwise healthy people between the ages of 6 up to 60. The swine flu was responsible for giving many middle aged people a death sentence.
Yeah we should be concerned, BUT as long as we take on our own ‘infection control’ we should be okay. This is common sense stuff we all should know, such as don’t share food or kiss an infected person. Wash your hands often and make sure its long enough, in health care we were taught wash those hands as you sing a verse of Happy birthday silently, use friction and its all good.
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